To promote clinical and translational research to provide advanced care that is currently unavailable for the residents of our Tristate Metro Community (West Virginia, Southern Ohio, and Eastern Kentucky). Since its creation, the Clinical Research Center has provided development and support to dozens of clinical trials, improving treatment for hundreds of patients.
Guiding Principles
Long Term Engagement
- Research Investigators are our long-term partners. The MCRC Seeks to build a lasting partnership with all of the researchers at the Joan C. Edwards School of Medicine.
Mutual Benefits
- The MCRC understands the role and pressures of being a primary investigator. It is our goal to enhance the environment, research, and reputation of each of our partners.
Professionalism
- The MCRC staff will work together with humility, candor, and mutual respect for expertise and cultural differences when communicating with researchers and community members.
Shared Responsibility
- All Partners have obligations towards the patients, the project, the community, and each other.
Integrity
- All decisions and actions will be based on optimizing best practices, maintaining data integrity, assuring safety, and upholding the highest standards of medical ethics and scientific quality.
Vision: We will be a world leader in community-academic clinical research supporting medical innovation and care in Appalachia. To realize this vision, we strive to:
- Develop a new standard for scholarship in clinical research.
- Nurture an environment of collaboration, creativity, and professional development throughout the Marshall research community.
- Foster a goal-oriented and balanced approach to research.
- Advance effective strategic alliances.
- Provide access to cutting-edge healthcare opportunities to the underserved community.
Clinical Trials Staff
- Usha Murughiyan (Assistant Dean for Clinical Trials)
- Nicole Finley – Lead Clinical Coordinator
- Amber Vickers – Clinical Coordinator
- David Coates – Clinical Coordinator
- Hillary Salava – Clinical Coordinator
- Gina Finley – Clinical Coordinator
- Jessica Merrick – Clinical Coordinator
- Mary Beth Cordle – Quality Officer
- Carlie Harrah – Executive Administrative Assistant
For more information regarding clinical trials, please contact Usha Murughiyan, (304)-691-1836, murughiyan@marshall.edu.
Active Clinical Trials |
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| Study ID | PI | Specialty | Disease Process | Enrollment Status | Description | Contact Information |
| NCT04173273 | Sundaram | Gastrointestinal | Crohn’s Disease | Yes | (CULTIVATE) Study Evaluating the Efficacy and Safety of Oral Etrasimod in the Treatment of Adult Participants With Moderately to Severely Active Crohn’s Disease | Nicole Finley |
| NCT05686070 | Lopez | Neurology | Acute Stroke | Yes | OCEANIC Stroke: A multicenter, international, randomized, placebo controlled, double-blind, parallel group and event driven Phase 3 study of the oral FXIa inhibitor asundexian (BAY 2433334) for the prevention of ischemic stroke in male and female participants aged 18 years and older after an acute non-cardioembolic ischemic stroke or high-risk TIA | Gina Finley |
| Sherif | Gastrointestinal | Cirrhosis | Not yet | RED-C: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Assess the Efficacy and Safety of Rifaximin Soluble Solid Dispersion (SSD) Tablets for the Delay of Encephalopathy Decompensation in Cirrhosis | Nicole Finley | |
| NCT06063967 | Sundaram | Gastrointestinal | Crohn’s Disease | Not yet | AFFIRM: A Phase 3, Randomized, Placebo-Controlled, Double-Blind Study to Evaluate the Efficacy and Safety of Risankizumab Subcutaneous Induction Treatment in Subjects with Moderately to Severely Active Crohn’s Disease | Nicole Finley |
| Sundaram | Gastrointestinal | Ulcerative Colitis | Not yet | LUTI: A Multicenter, Randomized Study to Evaluate the Safety and Efficacy of Lutikizumab for Induction and Maintenance Therapy in Subjects with Moderately to Severely Active Ulcerative Colitis |
Nicole Finley | |
| NCT05776225 | Al-Astal | Pulmonology | Pulmonary Hypertension | Not yet | PHINDER: Pulmonary Hypertension Screening in Patients with Interstitial Lung Disease for Earlier Detection |
Amber Diehl |
| NCT05970263 | Khawaja | Pulmonology |
COPD |
Not yet | IKANOS: A Prospective, Open-Label, Minimally Interventional Hybrid Study in the US Comparing Initiation of Breztri Maintenance versus Any Non-Triple Inhaled Therapy at Discharge after a Hospitalization for a COPD Exacerbation |
Gina Finley |
| Khawaja | Pulmonology |
Post-Acute Sequelae of SARS-CoV-2 Infection (PASC |
Not yet | Junonia: Postpartum Depression Longitudinal Study: A Care Coordination Intervention | Hillary Salava | |
| NCT05905926 | Villa | Pediatric Gastrointestinal |
IBS-Constipation |
Not yet | RALLY: A 12-Week, Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study to Assess the Safety and Efficacy of Tenapanor for the Treatment of Irritable Bowel Syndrome with Constipation (IBS-C) in Pediatric Patients 12 to Less than 18 Years Old | Jessica Merrick |
| NCT04396236 | Lopez | Neurology | Pediatric Migraine | Yes | (PIONEER-PEDS1) A Study of Lasmiditan (LY573144) Treatment in Children Aged 6 to 17 With Migraine | David Coates |
| NCT04396574 | Lopez | Neurology | Pediatric Migraine | Yes | (PIONEER-PEDS2) A 12-Month Study of Lasmiditan (LY573144) Treatment in Children Aged 6 to 17 With Migraine | David Coates |
| TP-201920 | Gentile | Orthopedic Surgery | Podiatric Screw Placement | Yes | (Trauma Screw) An Observational Study to Gather Real-World Data on the Tyber Medical Trauma Screw System | Daniell Gallagher |
| P255-501 | Lopez | Neurology | Pediatric Migraine | Yes | (ROAR) A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Phase 4 Study to Evaluate the Efficacy and Safety of Qudexy® XR in the Prevention of Migraine in Children 6 to 11 Years of Age | David Coates |
| NCT04821310 | Villa | Gastrointestinal | Erosive Esophagitis | Yes | (KEEP)An Exploratory, Multicenter, Randomized, Double-Blind Study of Clinical Outcomes, Tolerability, and Safety of 2 Doses of Oral Pantoprazole in Pediatric Participants, Aged 1 to 11 Years and 12 to 17 Years Who Require Maintenance Therapy for Healed Erosive Esophagitis | David Coates |
| NTC04938830 | Shields | Pediatrics | RSV | Yes | (Asservo) – A Phase 3, Multicenter, Randomized, Partially Blinded, Palivizumab- Controlled Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of MK-1654 in Infants and Children at Increased Risk for Severe RSV Disease | Gina Finley |
| NCT03887715 | Holroyd | Mental Health | Treatment-Resistant Depression | Yes | (RECOVER) – A PRospective, Multi-cEnter, Randomized Controlled Blinded Trial DemOnstrating the Safety and Effectiveness of VNS Therapy® System as AdjunctivE Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression | Hillary Salava |
| 964144 | Sundaram | Gastrointestinal | NIH/RO1 Grant | Yes | Regulation of Intestinal Nutrient and Electrolyte Transport in Chronic Disease | Jennifer Haynes; Nicole Finley |
| NCT0564172 | Lopez | Neurology | Pediatric Migraine | Yes | (REJOIN) Long-term Open Label (Dose-Blinded), Extension Study of Eptinezumab in Children and Adolescents with Chronic or Episodic Migraine | Jessica Merrick |
| NCT05242471 | Sundaram | Gastrointestinal | Chron’s Disease | Yes | (DUET-CD) – A Phase 2b Randomized, Double-blind, Active- and Placebo-controlled, Parallel-group, Multicenter Study to Evaluate the Efficacy and Safety of Induction and Maintenance Combination Therapy with Guselkumab and Golimumab in Participants with Moderately to Severely Active Crohn’s Disease | Nicole Finley |
| NCT04965675 | Lopez | Neurology | Pediatric Migraine | Yes | Interventional, randomized, double-blind, parallel group, placebo-controlled study to evaluate the efficacy and safety of IV eptinezumab in adolescents (12-17 years) for the preventative treatment of chronic migraine. | Jessica Merrick |
| N/A | Sundaram/Haynes | COBRE | Development of Organoids | Yes | Regulation of Intestinal Nutrient and Electrolyte Transport in chronic Disease | Jennifer Haynes |
| N/A | Sundaram/Singh | COBRE | Adipose Derived Secretome/Absorption | Yes | Adipose derived secretome (ADS) uniquely regulates intestinal epithelial cell nutrient absorption during obesity. | Soudamani Singh |
| N/A | Sundaram / Palaniappan | COBRE | Adenoma / Colorectal Cancer | Yes | Mechanism of regulation of Down regulated Adenoma (DRA) transporter in obesity associated colitis. | Bala Palaniappan |
| 499630 | Koester | Orthopedic Surgery | Metacarpal Tendon Repair | Yes | Humanitarian Use Device (HUD) for surgical repair of metacarpal tendon. | Dr. Koester/ Mary Beth Cordle |
| 463451 | Koester | Orthopedic Surgery | Metacarpal Tendon Repair | Yes | Humanitarian Use Device (HUD) for surgical repair of metacarpal tendon. | Dr. Koester/ Mary Beth Cordle |
| 964144 | Sundaram / Arthur | RO1 / COBRE | Nutrient and Electrolyte Transport | Yes | Regulation of Intestinal Nutrient and Electrolyte Transport in Chronic Disease | Subha Arthur |
| N/A | Sundaram / Cecchetti | DCTS / COBRE | Integrating Biology | Yes | Marshall University School of Medicine Informatics for Integrating to the Biology to the Bedside (I2B2) | Alfred Cecchetti |
| N/A | Sundaram / Cecchetti | DCTS / COBRE | Helicobacter Pylori | Yes | Helicobacter Pylori ( H. Pylori) in Apppalachia | Jacqueline Cavendish |
| N/A | Sundaram / Cecchetti | DCTS / COBRE | Metabolic Syndrome Classification | Yes | Classification of Metabolic Syntrome Patients Using a Data Warehouse Developed Algorithm | Alfred Cecchetti |
Updated on January 22, 2024
