Publications

Umapathy Sundaram, M.D.

Palaniappan B, Sundaram S, Arthur S  and Sundaram U. Intracellular mechanism of regulation of intestinal epithelial cell Na:H exchange by constitutive nitric oxide. Submitted.  Am. J . Physiol. Cell Physiology. 2022

Palaniappan B and Sundaram U. Direct and specific inhibition of constitutive nitric oxide synthase uniquely regulates brush border membrane Na-absorptive pathways in intestinal epithelial cells. Submitted. Am. J . Physiol. Gastro. & Liver. 2022

Haynes, J, Palaniappan B, Tsopmega, E, Sundaram U. Regulation of nutrient and electrolyte absorption in human organoid derived intestinal epithelial cell monolayers. Translational Research. In Press. 2022. May 2:S1931-5244(22)00099-8. doi: 10.1016/j.trsl.2022.04.008

Wellington VNA, Sundaram VL, Singh S, Sundaram U. Dietary Supplementation with Vitamin D, Fish Oil or Resveratrol Modulates the Gut Microbiome in Inflammatory Bowel Disease. Int J Mol Sci. 2021 Dec 24;23(1):206. doi: 10.3390/ijms23010206. PMID: 35008631; PMCID: PMC8745446

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Subha Arthur, Ph.D.

Butts M, Singh S, Haynes J, Arthur S, Sundaram U. Moderate Alcohol Consumption Uniquely Regulates Sodium-Dependent Glucose Co-Transport in Rat Intestinal Epithelial Cells In Vitro and In Vivo. J Nutr. 2020 Apr 1;150(4):747-755. doi: 10.1093/jn/nxz277. PubMed PMID: 31769840; PubMed Central PMCID: PMC7138678

Singh S, Arthur S, Sundaram U. Mechanisms of Regulation of Transporters of Amino Acid Absorption in Inflammatory Bowel Diseases. Compr Physiol. 2020 Mar 12;10(2):673-686. doi: 10.1002/cphy.c190016. Review. PubMed PMID: 32163200

Butts M, Singh Paulraj R, Haynes J, Arthur S, Singh S, Sundaram U. Moderate Alcohol Consumption Inhibits Sodium-Dependent Glutamine Co-Transport in Rat Intestinal Epithelial Cells in Vitro and Ex Vivo. Nutrients. 2019 Oct 18;11(10). doi: 10.3390/nu11102516. PubMed PMID: 31635319; PubMed Central PMCID: PMC6835445.

Sundaram S, Palaniappan B, Nepal N, Chaffins S, Sundaram U, Arthur S. Mechanism of Dyslipidemia in Obesity-Unique Regulation of Ileal Villus Cell Brush Border Membrane Sodium-Bile Acid Cotransport. Cells. 2019 Oct 3;8(10). doi: 10.3390/cells8101197. PubMed PMID: 31623375; PubMed Central PMCID: PMC6830326.

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Soudamani Singh, Ph.D.

Wellington VNA, Sundaram VL, Singh S, Sundaram U. Dietary Supplementation with Vitamin D, Fish Oil or Resveratrol Modulates the Gut Microbiome in Inflammatory Bowel Disease. Int J Mol Sci. 2021 Dec 24;23(1). doi: 10.3390/ijms23010206. Review. PubMed PMID: 35008631; PubMed Central PMCID: PMC8745446.

Nepal N, Arthur S, Butts MR, Singh S, Palaniappan B, Sundaram U. Molecular Mechanism of Stimulation of Na-K-ATPase by Leukotriene D4 in Intestinal Epithelial Cells. Int J Mol Sci. 2021 Jul 15;22(14). doi: 10.3390/ijms22147569. PubMed PMID: 34299188; PubMed Central PMCID: PMC8303499.
Thompson C, Rahman MM, Singh S, Arthur S, Sierra-Bakhshi C, Russell R, Denning K, Sundaram U, Salisbury T. The Adipose Tissue-Derived Secretome (ADS) in Obesity Uniquely Induces L-Type Amino Acid Transporter 1 (LAT1) and mTOR Signaling in Estrogen-Receptor-Positive Breast Cancer Cells. Int J Mol Sci. 2021 Jun 23;22(13). doi: 10.3390/ijms22136706. PubMed PMID: 34201429; PubMed Central PMCID: PMC8268498.
Butts M, Singh S, Haynes J, Arthur S, Sundaram U. Moderate Alcohol Consumption Uniquely Regulates Sodium-Dependent Glucose Co-Transport in Rat Intestinal Epithelial Cells In Vitro and In Vivo. J Nutr. 2020 Apr 1;150(4):747-755. doi: 10.1093/jn/nxz277. PubMed PMID: 31769840; PubMed Central PMCID: PMC7138678.

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Balasubramanian Palaniappan, Ph.D.

Arthur S, Palaniappan B, Afroz S, Sundaram U. Unique Regulation of Coupled NaCl Absorption by Inducible Nitric Oxide in a Spontaneous SAMP1/YitFc Mouse Model of Chronic Intestinal Inflammation. Inflamm Bowel Dis. 2021 Oct 20;27(11):1804-1812. doi: 10.1093/ibd/izab093. PubMed PMID: 34019094; PubMed Central PMCID: PMC8528149.

Nepal N, Arthur S, Butts MR, Singh S, Palaniappan B, Sundaram U. Molecular Mechanism of Stimulation of Na-K-ATPase by Leukotriene D4 in Intestinal Epithelial Cells. Int J Mol Sci. 2021 Jul 15;22(14). doi: 10.3390/ijms22147569. PubMed PMID: 34299188; PubMed Central PMCID: PMC8303499.
Nepal N, Arthur S, Haynes J, Palaniappan B, Sundaram U. Mechanism of Na-K-ATPase Inhibition by PGE2 in Intestinal Epithelial Cells. Cells. 2021 Mar 29;10(4). doi: 10.3390/cells10040752. PubMed PMID: 33805551; PubMed Central PMCID: PMC8066871.
Palaniappan B, Sundaram S, Arthur S, Afroz S, Sundaram U. Inducible Nitric Oxide Regulates Na-Glucose Co-transport in a Spontaneous SAMP1/YitFc Mouse Model of Chronic Ileitis. Nutrients. 2020 Oct 13;12(10). doi: 10.3390/nu12103116. PubMed PMID: 33065982; PubMed Central PMCID: PMC7600670.

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Alip Borthakur, Ph.D.

Priyamvada S, Anbazhagan AN, Kumar A, Chatterjee I, Borthakur A, Saksena S, Gill RK, Alrefai WA, Dudeja PK. All-trans Retinoic Acid Counteracts Diarrhea and Inhibition of Downregulated in Adenoma Expression in Gut Inflammation. Inflamm Bowel Dis. 2019

Kumar A, Jayawardena D, Anbazhagan AN, Chatterjee I, Priyamvada S, Gill RK, Alrefai WA, Borthakur A, Dudeja PK (2019). Decreased SLC26A3 expression and function in intestinal epithelial cells in response to Cryptosporidium parvum infection. Am J Physiol Cell Physiol 317, C1205-1212 *Corresponding author
Anbazhagan AN, Priyamvada S, Borthakur A, Saksena S, Gill RK, Alrefai WA Dudeja PK (2019). miR-125a-5p: A Novel Regulator of SLC26A6 Expression in Intestinal Epithelial Cells). Am J Physiol Cell Physiol 317, C200-C208
Kumar A, Chatterjee I, Anbazhagan AN, Jayawardena D, Priyamvada S, Alrefai WA, Sun J, Borthakur A, Dudeja PK (2018). Cryptosporidium parvum disrupts intestinal epithelial barrier function via altering expression of key tight junction and adherens junction proteins. Cellular Microbiology 20, e12830, 1-13 *Corresponding author

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Jennifer Haynes, Ph.D.

Nepal N, Arthur S, Haynes J, Palaniappan B, Sundaram U. Mechanism of Na-K-ATPase Inhibition by PGE2 in Intestinal Epithelial Cells. Cells. 2021 Mar 29;10(4). doi: 10.3390/cells10040752. PubMed PMID: 33805551; PubMed Central PMCID: PMC8066871.

Rehman SK, Haynes J, Collignon E, Brown KR, Wang Y, Nixon AML, Bruce JP, Wintersinger JA, Singh Mer A, Lo EBL, Leung C, Lima-Fernandes E, Pedley NM, Soares F, McGibbon S, He HH, Pollet A, Pugh TJ, Haibe-Kains B, Morris Q, Ramalho-Santos M, Goyal S, Moffat J, O’Brien CA. Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy. Cell. 2021 Jan 7;184(1):226-242.e21. doi: 10.1016/j.cell.2020.11.018. PubMed PMID: 33417860; PubMed Central PMCID: PMC8437243.
Butts M, Singh S, Haynes J, Arthur S, Sundaram U. Moderate Alcohol Consumption Uniquely Regulates Sodium-Dependent Glucose Co-Transport in Rat Intestinal Epithelial Cells In Vitro and In Vivo. J Nutr. 2020 Apr 1;150(4):747-755. doi: 10.1093/jn/nxz277. PubMed PMID: 31769840; PubMed Central PMCID: PMC7138678.
Butts M, Singh Paulraj R, Haynes J, Arthur S, Singh S, Sundaram U. Moderate Alcohol Consumption Inhibits Sodium-Dependent Glutamine Co-Transport in Rat Intestinal Epithelial Cells in Vitro and Ex Vivo. Nutrients. 2019 Oct 18;11(10). doi: 10.3390/nu11102516. PubMed PMID: 31635319; PubMed Central PMCID: PMC6835445.

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Rajan Lamichhane, Ph.D.

Lelegren M, Bhat K, Sheehan B, Lamichhane R, Han JK, Lam KK. Variations in utilization and clinical outcomes for endoscopic sphenopalatine artery ligation and endovascular arterial embolization in a single multi-hospital network. Am J Otolaryngol. 2021 Nov-Dec;42(6):103066. doi: 10.1016/j.amjoto.2021.103066. Epub 2021 Apr 16. PubMed PMID: 33934006.

Zhang Q, Lamichhane R, Wouk K, Guthrie J, Li K. Prenatal perception of breastfeeding recommendation predicts early breastfeeding outcomes of participants in the Supplemental Nutrition Program for Women, Infants, and Children (WIC). Am J Clin Nutr. 2021 Jul 24;. doi: 10.1093/ajcn/nqab268. [Epub ahead of print] PubMed PMID: 34302329; PubMed Central PMCID: PMC8634569.
Fahrmann ER, Adkins LJ, Lamichhane R, Driscoll H. Effect of Severe Hypoglycemia on Myocardial Cardiac Function in Type 1 Diabetes. Diabetes. 2021 June; 70.
Amin ARMR, Wang D, Nannapaneni S, Lamichhane R, Chen ZG, Shin DM. Combination of resveratrol and green tea epigallocatechin gallate induces synergistic apoptosis and inhibits tumor growth in vivo in head and neck cancer models. Oncol Rep. 2021 May;45(5). doi: 10.3892/or.2021.8038. Epub 2021 Apr 13. PubMed PMID: 33864659; PubMed Central PMCID: PMC8025073.

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Alfred Ceccehetti, Ph.D. MSc, MSc IS

Cecchetti AA, Bhardwaj N, Murughiyan U, Kothakapu G, Sundaram U. Fueling Clinical and Translational Research in Appalachia: Informatics Platform Approach. JMIR Med Inform. 2020 Oct 14;8(10):e17962. doi: 10.2196/17962. PMID: 33052114; PMCID: PMC7593861.

Bhardwaj N, Cecchetti AA, Murughiyan U, Neitch S. Analysis of Benzodiazepine Prescription Practices in Elderly Appalachians with Dementia via the Appalachian Informatics Platform: Longitudinal Study. JMIR Med Inform. 2020 Aug 4;8(8):e18389. doi: 10.2196/18389. PMID: 32749226; PMCID: PMC7435704.
Cecchetti AA, Parmanto B, Vecchio ML, Ahmad S, Buch S, Zgheib NK, Groark SJ Jr, Vemuganti A, Romkes M, Sciurba F, Donahoe MP, Branch RA. Team building: electronic management-clinical translational research (eM-CTR) systems. Clin Transl Sci. 2009 Dec;2(6):449-55. doi: 10.1111/j.1752-8062.2009.00157.x. PMID: 20443940; PMCID: PMC3687802.
Pancoska P, Buch S, Cecchetti A, Parmanto B, Vecchio M, Groark S, Paulsen S, Bardwell G, Morton C, Chester A, Branch R. Family networks of obesity and type 2 diabetes in rural Appalachia. Clin Transl Sci. 2009 Dec;2(6):413-21. doi: 10.1111/j.1752-8062.2009.00162.x. PMID: 20443933; PMCID: PMC4703323.

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